Assay Detail
Binding
CHEMBL4617985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate incubated for 20 hrs by scintillation spectrometry analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | JEG-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.79 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286738 | IROSUSTAT | 2.0 | 1 | 8.68 |
| CHEMBL4635151 | — | — | 1 | 7.87 |
| CHEMBL4637433 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286738 | IROSUSTAT | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4635151 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL4637433 | — | IC50 | = | 150.0 | nM | 6.82 |