Assay Detail
Functional
CHEMBL4618004
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Antiviral activity against TBEV Absettarov infected in porcine PEK cells assessed as inhibition of viral reproduction by measuring plaque reduction preincubated for 1 hr followed by overlaying with 1.26% methylcellulose and measured after 6 days by gentian violet staining-based assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Tick-borne encephalitis virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Tick-borne encephalitis virus (CHEMBL4296604) ↗| Type | ORGANISM |
| Organism | Tick-borne encephalitis virus |
Publication
Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.60 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642380 | — | — | 1 | 8.80 |
| CHEMBL4644615 | — | — | 1 | 8.41 |
| CHEMBL4638713 | — | — | 1 | 8.22 |
| CHEMBL4634980 | — | — | 1 | 8.11 |
| CHEMBL4634995 | — | — | 1 | 8.10 |
| CHEMBL4648573 | — | — | 1 | 8.05 |
| CHEMBL4649207 | — | — | 1 | 7.82 |
| CHEMBL3797928 | — | — | 1 | 7.68 |
| CHEMBL4640599 | — | — | 1 | 7.60 |
| CHEMBL4648813 | — | — | 1 | 7.43 |
| CHEMBL4644238 | — | — | 1 | 7.05 |
| CHEMBL1320139 | HELIOMYCIN | 2.0 | 1 | 6.82 |
| CHEMBL4102485 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642380 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4644615 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4638713 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4634980 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4634995 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4648573 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4649207 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3797928 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4640599 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4648813 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4644238 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1320139 | HELIOMYCIN | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4102485 | — | EC50 | = | 22000.0 | nM | 4.66 |