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Compound Detail

CHEMBL4648573

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O=C(NCCCCO)c1ccc(-c2ccc3c4cccc5cccc(c6cccc2c63)c54)s1

Basic Information

ChEMBL ID CHEMBL4648573
Phase Preclinical
Structure Type MOL
InChI Key RSEZXSGQRHRYLE-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

449.6
MW (Da)
6.97
ALogP
3
HBA
2
HBD
49.3
PSA (Ų)
0.16
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H23NO2S
MW 449.58
Aromatic Rings 6
Heavy Atoms 33
NP-Likeness -0.25

Activity Summary

EC50 1 meas. best 8.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Tick-borne encephalitis virus
CHEMBL4296604
EC50 8.05 8.05 9.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
32199731 10.1016/j.bmcl.2020.127100 Unchecked 2
32199731 10.1016/j.bmcl.2020.127100 Tick-borne encephalitis virus 1

Data from ChEMBL 36 via Core Engine