Assay Detail
Binding
CHEMBL4618042
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Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine as substrate preincubated for 30 mins followed by substrate addition and measured after 2 mins by Ellman's method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Furofuranone Lignans from <i>Leucophyllum ambiguum</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.93 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647106 | — | — | 1 | 9.00 |
| CHEMBL4634863 | — | — | 1 | 8.52 |
| CHEMBL4633410 | — | — | 1 | 7.55 |
| CHEMBL4633613 | — | — | 1 | 6.80 |
| CHEMBL1980572 | — | — | 1 | 6.34 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 6.27 |
| CHEMBL454592 | — | — | 1 | 6.21 |
| CHEMBL519926 | — | — | 1 | 6.04 |
| CHEMBL4632461 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647106 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4634863 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4633410 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4633613 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL1980572 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 538.0 | nM | 6.27 |
| CHEMBL454592 | — | IC50 | = | 616.0 | nM | 6.21 |
| CHEMBL519926 | — | IC50 | = | 903.0 | nM | 6.04 |
| CHEMBL4632461 | — | IC50 | = | 2229.0 | nM | 5.65 |