Assay Detail
Binding
CHEMBL4618265
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Inhibition of human factor11a using pyro-Glu-Pro-Arg-pNA(para-nitroaniline) substrate by spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.81 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4638245 | — | — | 1 | 9.59 |
| CHEMBL4646341 | — | — | 1 | 9.30 |
| CHEMBL4646441 | — | — | 1 | 9.22 |
| CHEMBL4644510 | — | — | 1 | 9.15 |
| CHEMBL4636247 | — | — | 1 | 9.05 |
| CHEMBL4637480 | — | — | 1 | 8.80 |
| CHEMBL4638837 | — | — | 1 | 8.74 |
| CHEMBL4639313 | — | — | 1 | 8.57 |
| CHEMBL4633639 | — | — | 1 | 8.35 |
| CHEMBL4635155 | — | — | 1 | 8.31 |
| CHEMBL4639498 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4638245 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL4646341 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4646441 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4644510 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4636247 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4637480 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4638837 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL4639313 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL4633639 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL4635155 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL4639498 | — | Ki | = | 14.0 | nM | 7.85 |