Assay Detail
Binding
CHEMBL4618345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant N-terminal GST-fused human NIK (319 to 947 residues) expressed in baculovirus expression system incubated for 120 mins in presence of ATP by ADP-glo based luminescence assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 14 (CHEMBL5888) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of N-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as Novel, Potent, and Selective NF-κB Inducing Kinase (NIK) Inhibitors for the Treatment of Psoriasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.04 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3187788 | — | — | 1 | 8.33 |
| CHEMBL4648033 | — | — | 1 | 8.18 |
| CHEMBL4644825 | — | — | 1 | 8.09 |
| CHEMBL4642561 | — | — | 1 | 8.06 |
| CHEMBL4645565 | — | — | 1 | 8.01 |
| CHEMBL4643621 | — | — | 1 | 7.94 |
| CHEMBL4636517 | — | — | 1 | 7.92 |
| CHEMBL4639487 | — | — | 1 | 7.82 |
| CHEMBL4634128 | — | — | 1 | 7.79 |
| CHEMBL4640754 | — | — | 1 | 7.75 |
| CHEMBL4636885 | — | — | 1 | 7.65 |
| CHEMBL4635451 | — | — | 1 | 7.46 |
| CHEMBL4636048 | — | — | 1 | 7.32 |
| CHEMBL4642847 | — | — | 1 | 7.30 |
| CHEMBL4643185 | — | — | 1 | 7.22 |
| CHEMBL4647027 | — | — | 1 | 7.16 |
| CHEMBL4639818 | — | — | 1 | 7.14 |
| CHEMBL4645354 | — | — | 1 | 7.11 |
| CHEMBL4642207 | — | — | 1 | 6.97 |
| CHEMBL4643436 | — | — | 1 | 6.95 |
| CHEMBL4642063 | — | — | 1 | 6.87 |
| CHEMBL4644359 | — | — | 1 | 6.75 |
| CHEMBL4635397 | — | — | 1 | 6.70 |
| CHEMBL4638853 | — | — | 1 | 6.68 |
| CHEMBL4648928 | — | — | 1 | 6.32 |
| CHEMBL4640652 | — | — | 1 | 6.19 |
| CHEMBL4648213 | — | — | 1 | 6.15 |
| CHEMBL4635659 | — | — | 1 | 5.90 |
| CHEMBL4640245 | — | — | 1 | 5.86 |
| CHEMBL4645612 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3187788 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4648033 | — | IC50 | = | 6.59 | nM | 8.18 |
| CHEMBL4644825 | — | IC50 | = | 8.22 | nM | 8.09 |
| CHEMBL4642561 | — | IC50 | = | 8.63 | nM | 8.06 |
| CHEMBL4645565 | — | IC50 | = | 9.87 | nM | 8.01 |
| CHEMBL4643621 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL4636517 | — | IC50 | = | 11.98 | nM | 7.92 |
| CHEMBL4639487 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL4634128 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL4640754 | — | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL4636885 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL4635451 | — | IC50 | = | 34.5 | nM | 7.46 |
| CHEMBL4636048 | — | IC50 | = | 47.9 | nM | 7.32 |
| CHEMBL4642847 | — | IC50 | = | 50.4 | nM | 7.30 |
| CHEMBL4643185 | — | IC50 | = | 60.1 | nM | 7.22 |
| CHEMBL4647027 | — | IC50 | = | 69.16 | nM | 7.16 |
| CHEMBL4639818 | — | IC50 | = | 72.4 | nM | 7.14 |
| CHEMBL4645354 | — | IC50 | = | 78.3 | nM | 7.11 |
| CHEMBL4642207 | — | IC50 | = | 106.7 | nM | 6.97 |
| CHEMBL4643436 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4642063 | — | IC50 | = | 135.7 | nM | 6.87 |
| CHEMBL4644359 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL4635397 | — | IC50 | = | 199.9 | nM | 6.70 |
| CHEMBL4638853 | — | IC50 | = | 209.5 | nM | 6.68 |
| CHEMBL4648928 | — | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL4640652 | — | IC50 | = | 645.0 | nM | 6.19 |
| CHEMBL4648213 | — | IC50 | = | 705.0 | nM | 6.15 |
| CHEMBL4635659 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4640245 | — | IC50 | = | 1378.0 | nM | 5.86 |
| CHEMBL4645612 | — | IC50 | = | 1404.0 | nM | 5.85 |
| CHEMBL4643512 | — | IC50 | = | 1639.0 | nM | 5.79 |
| CHEMBL4645639 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL4641000 | — | IC50 | = | 2714.0 | nM | 5.57 |
| CHEMBL4642638 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4632558 | — | IC50 | - | — | - | |
| CHEMBL4640623 | — | IC50 | - | — | - |