Assay Detail
Binding
CHEMBL4618910
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Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in presence of acetyl CoA by SPR analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of Specific <i>N</i>-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.63 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4645901 | — | — | 1 | 7.57 |
| CHEMBL4645967 | — | — | 1 | 6.33 |
| CHEMBL4635926 | — | — | 1 | 6.00 |
| CHEMBL4633201 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4645901 | — | Kd | = | 26.7 | nM | 7.57 |
| CHEMBL4645967 | — | Kd | = | 470.0 | nM | 6.33 |
| CHEMBL4635926 | — | Kd | = | 1010.0 | nM | 6.00 |
| CHEMBL4633201 | — | Kd | > | 10000.0 | nM | - |