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Target Snapshot

CHEMBL4630854 Target Snapshot

N-alpha-acetyltransferase 50 · SINGLE PROTEIN · Homo sapiens

23Compounds
17Assays
0Approved Drugs
28.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9GZZ1. Use UniProt Q9GZZ1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9GZZ1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats N-alpha-acetyltransferase 50 as ChEMBL target CHEMBL4630854, mapped to UniProt Q9GZZ1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
N-alpha-acetyltransferase 50
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4630854
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9GZZ1
N-alpha-acetyltransferase 50
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether N-alpha-acetyltransferase 50 is the right protein anchor across sources, using UniProt Q9GZZ1 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelN-alpha-acetyltransferase 50
UniProt AccessionQ9GZZ1
Component TypeProtein
Sequence Length169 aa

N-alpha-acetyltransferase 50

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as N-alpha-acetyltransferase 50, mapped to UniProt Q9GZZ1. Sequence length is 169 aa.

Mapped IDQ9GZZ1
Review nameN-alpha-acetyltransferase 50
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC5018.0
KD10.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4645901 8.15 IC50 7.0 Preclinical
CHEMBL4642700 7.89 IC50 13.0 Preclinical
CHEMBL4642788 7.89 IC50 13.0 Preclinical
CHEMBL4639216 7.85 IC50 14.0 Preclinical
CHEMBL1230809 7.75 Kd 17.6 Preclinical
CHEMBL4645901 7.57 Kd 26.7 Preclinical
CHEMBL4642911 7.52 IC50 30.0 Preclinical
CHEMBL4644527 7.06 IC50 88.0 Preclinical
CHEMBL1213327 6.81 Kd 156.0 Clinical
CHEMBL4636177 6.77 IC50 170.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
5
5.5
5
6.0
3
6.5
1
7.0
7
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

17
Total Assays
21
Tested Compounds
1
Assay Types
Binding — 17 assays, 21 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 20 6.5
single protein format 2 1 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine