Compound Detail
CHEMBL4642911
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CSCC[C@H](NC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(N)=O
Basic Information
| ChEMBL ID | CHEMBL4642911 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VUXCLHXSYVWEGK-IBWOJKGTSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1223.1
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| N-alpha-acetyltransferase 50 CHEMBL4630854 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N-alpha-acetyltransferase 50 | IC50 | = | 30.0 | nM | 7.52 | Inhibition of wild type human Naa50 (1852 to 2082 residues) expressed in Escheri... | 32550998 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32550998 | 10.1021/acsmedchemlett.0c00029 | N-alpha-acetyltransferase 50 | 1 |
Data from ChEMBL 36 via Core Engine