Assay Detail
Binding
CHEMBL4618909
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Inhibition of wild type human Naa50 (1852 to 2082 residues) expressed in Escherichia coli BL21(DE3) cells using MLGPEGGEGK peptide as substrate after 75 mins in presence of acetyl CoA by rapidfire mass spectrometry analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of Specific <i>N</i>-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.28 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4645901 | — | — | 1 | 8.15 |
| CHEMBL4642788 | — | — | 1 | 7.89 |
| CHEMBL4642700 | — | — | 1 | 7.89 |
| CHEMBL4639216 | — | — | 1 | 7.85 |
| CHEMBL4642911 | — | — | 1 | 7.52 |
| CHEMBL4644527 | — | — | 1 | 7.06 |
| CHEMBL4636177 | — | — | 1 | 6.77 |
| CHEMBL4648534 | — | — | 1 | 6.37 |
| CHEMBL4640907 | — | — | 1 | 6.00 |
| CHEMBL4645967 | — | — | 1 | 5.80 |
| CHEMBL4635926 | — | — | 1 | 5.70 |
| CHEMBL4635301 | — | — | 1 | 5.57 |
| CHEMBL4636574 | — | — | 1 | 5.54 |
| CHEMBL4632414 | — | — | 1 | 5.41 |
| CHEMBL4634916 | — | — | 1 | 4.98 |
| CHEMBL4633201 | — | — | 1 | 4.92 |
| CHEMBL4645057 | — | — | 1 | 4.89 |
| CHEMBL4637072 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4645901 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4642788 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4642700 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4639216 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4642911 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4644527 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4636177 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4648534 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4640907 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4645967 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4635926 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4635301 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4636574 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4632414 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4634916 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4633201 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4645057 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4637072 | — | IC50 | = | 21000.0 | nM | 4.68 |