Assay Detail
Functional
CHEMBL4619595
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Antiproliferative activity against human K562 cells incubated for 3 days by CCK8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Global PROTAC Toolbox for Degrading BCR-ABL Overcomes Drug-Resistant Mutants and Adverse Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.34 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 9.72 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 9.52 |
| CHEMBL4208229 | ASCIMINIB | 4.0 | 1 | 9.21 |
| CHEMBL4640401 | — | — | 1 | 8.12 |
| CHEMBL4642168 | — | — | 1 | 8.10 |
| CHEMBL4639867 | — | — | 1 | 8.04 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 7.12 |
| CHEMBL4640733 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4208229 | ASCIMINIB | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL4640401 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4642168 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4639867 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL941 | IMATINIB | IC50 | = | 76.2 | nM | 7.12 |
| CHEMBL4640733 | — | IC50 | = | 121.0 | nM | 6.92 |