Compound Detail
CHEMBL4639867
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Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCc3cn(CCOCCOCCOCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)nn3)CC2)n1
Basic Information
| ChEMBL ID | CHEMBL4639867 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BCHARVWLDCVBSQ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
1056.6
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| K562 CHEMBL385 | IC50 | 8.04 | 8.04 | 9.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| K562 | IC50 | = | 9.2 | nM | 8.04 | Antiproliferative activity against human K562 cells incubated for 3 days by CCK8... | 32657579 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32657579 | 10.1021/acs.jmedchem.0c00967 | Protein cereblon/BCR/ABL | 3 |
| 32657579 | 10.1021/acs.jmedchem.0c00967 | K562 | 1 |
| 32657579 | 10.1021/acs.jmedchem.0c00967 | BaF3 | 1 |
Data from ChEMBL 36 via Core Engine