Assay Detail
Binding
CHEMBL4619650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His-tagged full length human HDAC8 expressed in baculovirus expression system using FAM-RHKK(TF-Ac)-NH2 substrate incubated for 3 hrs by EMSA method
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.92 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170177 | — | — | 1 | 8.39 |
| CHEMBL4642821 | — | — | 1 | 7.63 |
| CHEMBL4638377 | — | — | 1 | 7.47 |
| CHEMBL4640819 | — | — | 1 | 7.26 |
| CHEMBL4641613 | — | — | 1 | 7.21 |
| CHEMBL4643684 | — | — | 1 | 7.19 |
| CHEMBL4649867 | — | — | 1 | 7.18 |
| CHEMBL4637798 | — | — | 1 | 7.18 |
| CHEMBL4642047 | — | — | 1 | 7.10 |
| CHEMBL4649514 | — | — | 1 | 7.08 |
| CHEMBL4649651 | — | — | 1 | 7.05 |
| CHEMBL4642398 | — | — | 1 | 6.97 |
| CHEMBL4637226 | — | — | 1 | 6.94 |
| CHEMBL4638505 | — | — | 1 | 6.92 |
| CHEMBL4643791 | — | — | 1 | 6.89 |
| CHEMBL4634713 | — | — | 1 | 6.65 |
| CHEMBL4640205 | — | — | 1 | 6.58 |
| CHEMBL4640536 | — | — | 1 | 6.51 |
| CHEMBL4641253 | — | — | 1 | 6.32 |
| CHEMBL4641390 | — | — | 1 | 6.19 |
| CHEMBL4636672 | — | — | 1 | 6.17 |
| CHEMBL4633998 | — | — | 1 | 6.14 |
| CHEMBL4633453 | — | — | 1 | 6.08 |
| CHEMBL4646090 | — | — | 1 | - |
| CHEMBL4637127 | — | — | 1 | - |
| CHEMBL4639383 | — | — | 1 | - |
| CHEMBL4644653 | — | — | 1 | - |
| CHEMBL4639051 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170177 | — | IC50 | = | 4.03 | nM | 8.39 |
| CHEMBL4642821 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL4638377 | — | IC50 | = | 33.7 | nM | 7.47 |
| CHEMBL4640819 | — | IC50 | = | 55.3 | nM | 7.26 |
| CHEMBL4641613 | — | IC50 | = | 62.3 | nM | 7.21 |
| CHEMBL4643684 | — | IC50 | = | 65.1 | nM | 7.19 |
| CHEMBL4649867 | — | IC50 | = | 65.5 | nM | 7.18 |
| CHEMBL4637798 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4642047 | — | IC50 | = | 79.8 | nM | 7.10 |
| CHEMBL4649514 | — | IC50 | = | 83.5 | nM | 7.08 |
| CHEMBL4649651 | — | IC50 | = | 88.5 | nM | 7.05 |
| CHEMBL4642398 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4637226 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL4638505 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4643791 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4634713 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL4640205 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL4640536 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL4641253 | — | IC50 | = | 478.0 | nM | 6.32 |
| CHEMBL4641390 | — | IC50 | = | 648.0 | nM | 6.19 |
| CHEMBL4636672 | — | IC50 | = | 682.0 | nM | 6.17 |
| CHEMBL4633998 | — | IC50 | = | 723.0 | nM | 6.14 |
| CHEMBL4633453 | — | IC50 | = | 823.0 | nM | 6.08 |
| CHEMBL4646090 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4637127 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4639383 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4644653 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4639051 | — | IC50 | > | 1000.0 | nM | - |