Assay Detail
Binding
CHEMBL4620017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KEAP1 interaction with Nrf2 (unknown origin) by SRP assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Kelch-like ECH-associated protein 1 (CHEMBL2069156) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.68 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4159561 | — | — | 1 | 5.70 |
| CHEMBL4159153 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4159561 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4159153 | — | IC50 | = | 2200.0 | nM | 5.66 |