Assay Detail
Binding
CHEMBL4620018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VHL (unknown origin) by fluorescence polarization assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
von Hippel-Lindau disease tumor suppressor (CHEMBL3108660) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.34 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4225537 | — | — | 1 | 7.06 |
| CHEMBL3344081 | — | — | 1 | 6.73 |
| CHEMBL3260851 | — | — | 1 | 6.17 |
| CHEMBL3108881 | — | — | 1 | 5.39 |
| CHEMBL4639001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4225537 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3344081 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL3260851 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3108881 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4639001 | — | IC50 | = | 117000.0 | nM | - |