Assay Detail
Binding
CHEMBL4620143
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Inhibition of AKR1B1 in rat lenses
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel quinolin-4(1H)-one derivatives as multi-effective aldose reductase inhibitors for treatment of diabetic complications: Synthesis, biological evaluation, and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.93 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4644582 | — | — | 1 | 7.24 |
| CHEMBL4634561 | — | — | 1 | 7.19 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.09 |
| CHEMBL4641309 | — | — | 1 | 7.01 |
| CHEMBL4637167 | — | — | 1 | 6.97 |
| CHEMBL4635967 | — | — | 1 | 6.95 |
| CHEMBL4648347 | — | — | 1 | 6.81 |
| CHEMBL4636966 | — | — | 1 | 6.62 |
| CHEMBL4648062 | — | — | 1 | 6.60 |
| CHEMBL4640803 | — | — | 1 | 6.54 |
| CHEMBL4647603 | — | — | 1 | 6.49 |
| CHEMBL4639244 | — | — | 1 | 6.20 |
| CHEMBL4633200 | — | — | 1 | 6.16 |
| CHEMBL4641528 | — | — | 1 | 5.82 |
| CHEMBL4640269 | — | — | 1 | 5.60 |
| CHEMBL4639059 | — | — | 1 | 5.00 |
| CHEMBL4637287 | — | — | 1 | 4.97 |
| CHEMBL595369 | — | — | 1 | 4.96 |
| CHEMBL608112 | — | — | 1 | 4.92 |
| CHEMBL4647238 | — | — | 1 | 4.90 |
| CHEMBL4644132 | — | — | 1 | 4.90 |
| CHEMBL4648778 | — | — | 1 | 4.89 |
| CHEMBL4646322 | — | — | 1 | 4.87 |
| CHEMBL4638403 | — | — | 1 | 4.82 |
| CHEMBL4643288 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4644582 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4634561 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL56337 | EPALRESTAT | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4641309 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4637167 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4635967 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4648347 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4636966 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL4648062 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL4640803 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL4647603 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL4639244 | — | IC50 | = | 626.0 | nM | 6.20 |
| CHEMBL4633200 | — | IC50 | = | 689.0 | nM | 6.16 |
| CHEMBL4641528 | — | IC50 | = | 1528.0 | nM | 5.82 |
| CHEMBL4640269 | — | IC50 | = | 2487.0 | nM | 5.60 |
| CHEMBL4639059 | — | IC50 | = | 9875.0 | nM | 5.00 |
| CHEMBL4637287 | — | IC50 | = | 10587.0 | nM | 4.97 |
| CHEMBL595369 | — | IC50 | = | 11017.0 | nM | 4.96 |
| CHEMBL608112 | — | IC50 | = | 12031.0 | nM | 4.92 |
| CHEMBL4647238 | — | IC50 | = | 12515.0 | nM | 4.90 |
| CHEMBL4644132 | — | IC50 | = | 12578.0 | nM | 4.90 |
| CHEMBL4648778 | — | IC50 | = | 12781.0 | nM | 4.89 |
| CHEMBL4646322 | — | IC50 | = | 13578.0 | nM | 4.87 |
| CHEMBL4638403 | — | IC50 | = | 15034.0 | nM | 4.82 |
| CHEMBL4643288 | — | IC50 | = | 15614.0 | nM | 4.81 |