Assay Detail
Functional
CHEMBL4620539
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Cytotoxicity against human K562 cells assessed as reduction in cell viability
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.67 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.52 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 8.46 |
| CHEMBL394931 | — | — | 1 | 5.32 |
| CHEMBL4638534 | — | — | 1 | 4.85 |
| CHEMBL4636793 | — | — | 1 | 4.75 |
| CHEMBL486827 | HERBIMYCIN C | — | 1 | 4.70 |
| CHEMBL4634888 | — | — | 1 | 4.37 |
| CHEMBL4633708 | — | — | 1 | 4.37 |
| CHEMBL4636777 | — | — | 1 | - |
| CHEMBL267792 | REBLASTATIN | — | 1 | - |
| CHEMBL401784 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL394931 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4638534 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4636793 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL486827 | HERBIMYCIN C | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4634888 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4633708 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4636777 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL267792 | REBLASTATIN | IC50 | - | — | - | |
| CHEMBL401784 | — | IC50 | - | — | - |