Assay Detail
Binding
CHEMBL4620613
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Inhibition of rat liver COMT using esculetin as substrate by fluorescence based spectrophotometry
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of nitrocatechol chalcone and pyrazoline derivatives as inhibitors of catechol-O-methyltransferase and monoamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.77 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4645524 | — | — | 1 | 7.32 |
| CHEMBL4646943 | — | — | 1 | 7.12 |
| CHEMBL4646711 | — | — | 1 | 7.10 |
| CHEMBL4638572 | — | — | 1 | 6.85 |
| CHEMBL4642660 | — | — | 1 | 6.80 |
| CHEMBL4649455 | — | — | 1 | 6.75 |
| CHEMBL4648330 | — | — | 1 | 6.75 |
| CHEMBL4646544 | — | — | 1 | 6.75 |
| CHEMBL4648085 | — | — | 1 | 6.72 |
| CHEMBL4646238 | — | — | 1 | 6.68 |
| CHEMBL953 | ENTACAPONE | 4.0 | 1 | 6.64 |
| CHEMBL4639456 | — | — | 1 | 6.64 |
| CHEMBL4637888 | — | — | 1 | 6.64 |
| CHEMBL4634068 | — | — | 1 | 6.62 |
| CHEMBL4645261 | — | — | 1 | 6.62 |
| CHEMBL4634215 | — | — | 1 | 6.54 |
| CHEMBL4636840 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4645524 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4646943 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4646711 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4638572 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4642660 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4649455 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4648330 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4646544 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4648085 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4646238 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL953 | ENTACAPONE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4639456 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4637888 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4634068 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4645261 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4634215 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4636840 | — | IC50 | = | 290.0 | nM | 6.54 |