Assay Detail
ADMET
CHEMBL4621220
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Substrate activity at OATP1B3 (unknown origin) expressed in HEK293 cells assessed as cytotoxicity incubated for 48 hrs by sulforhodamine B assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier organic anion transporter family member 1B3 (CHEMBL1743121) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Precursor-Directed Biosynthesis and Fluorescence Labeling of Clickable Microcystins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.66 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636474 | — | — | 1 | 8.85 |
| CHEMBL4637446 | — | — | 1 | 8.62 |
| CHEMBL4633668 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636474 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4637446 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4633668 | — | EC50 | = | 3.0 | nM | 8.52 |