Assay Detail
Binding
CHEMBL4621287
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV/EBOV GP Y517S mutant infected in 293T cells assessed as reduction in virus entry
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ebolavirus |
| Cell Type | HEK-293T |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Envelope glycoprotein (CHEMBL4105829) ↗| Type | SINGLE PROTEIN |
| Organism | Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) |
Publication
Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| EC50 | 1 | 7.20 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1655 | TOREMIFENE | 4.0 | 1 | 7.20 |
| CHEMBL4644544 | — | — | 1 | - |
| CHEMBL4640931 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1655 | TOREMIFENE | EC50 | = | 62.8 | nM | 7.20 |
| CHEMBL4644544 | — | Inhibition | - | % | - | |
| CHEMBL4640931 | — | Inhibition | - | % | - |