Assay Detail
Binding
CHEMBL4621458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of human utrophinA expressed in mouse H2K cells assessed as upregulation of utrophin production after 24 hrs by luciferase reporter gene assay
57
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Arylbenzo[<i>d</i>]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 57 | 6.52 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639067 | — | — | 1 | 8.40 |
| CHEMBL4639832 | — | — | 1 | 8.00 |
| CHEMBL4641041 | — | — | 1 | 7.58 |
| CHEMBL4645628 | — | — | 1 | 7.47 |
| CHEMBL4637833 | — | — | 1 | 7.42 |
| CHEMBL4647136 | — | — | 1 | 7.21 |
| CHEMBL4643175 | — | — | 1 | 7.15 |
| CHEMBL4638445 | — | — | 1 | 7.15 |
| CHEMBL4638708 | — | — | 1 | 7.07 |
| CHEMBL4634557 | — | — | 1 | 6.97 |
| CHEMBL4636035 | — | — | 1 | 6.96 |
| CHEMBL4638463 | — | — | 1 | 6.95 |
| CHEMBL4633264 | — | — | 1 | 6.93 |
| CHEMBL4638592 | — | — | 3 | 6.91 |
| CHEMBL4644129 | — | — | 1 | 6.84 |
| CHEMBL4637813 | — | — | 1 | 6.83 |
| CHEMBL4644346 | — | — | 1 | 6.80 |
| CHEMBL4633235 | — | — | 1 | 6.79 |
| CHEMBL4635899 | — | — | 1 | 6.79 |
| CHEMBL4638950 | — | — | 1 | 6.78 |
| CHEMBL1773683 | EZUTROMID | 2.0 | 1 | 6.73 |
| CHEMBL4646007 | — | — | 1 | 6.70 |
| CHEMBL4636283 | — | — | 1 | 6.63 |
| CHEMBL4645547 | — | — | 1 | 6.61 |
| CHEMBL4647847 | — | — | 1 | 6.52 |
| CHEMBL4646025 | — | — | 1 | 6.48 |
| CHEMBL4640211 | — | — | 1 | 6.26 |
| CHEMBL4648719 | — | — | 1 | 6.12 |
| CHEMBL4633558 | — | — | 1 | 6.11 |
| CHEMBL4646039 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639067 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4639832 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4641041 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4645628 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4637833 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4647136 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4638445 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4643175 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4638708 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4634557 | — | EC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4636035 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4638463 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4633264 | — | EC50 | = | 118.0 | nM | 6.93 |
| CHEMBL4638592 | — | EC50 | = | 124.0 | nM | 6.91 |
| CHEMBL4644129 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4637813 | — | EC50 | = | 148.0 | nM | 6.83 |
| CHEMBL4644346 | — | EC50 | = | 157.0 | nM | 6.80 |
| CHEMBL4635899 | — | EC50 | = | 164.0 | nM | 6.79 |
| CHEMBL4633235 | — | EC50 | = | 163.0 | nM | 6.79 |
| CHEMBL4638950 | — | EC50 | = | 168.0 | nM | 6.78 |
| CHEMBL1773683 | EZUTROMID | EC50 | = | 187.0 | nM | 6.73 |
| CHEMBL4646007 | — | EC50 | = | 198.0 | nM | 6.70 |
| CHEMBL4636283 | — | EC50 | = | 234.0 | nM | 6.63 |
| CHEMBL4638592 | — | EC50 | = | 244.0 | nM | 6.61 |
| CHEMBL4645547 | — | EC50 | = | 244.0 | nM | 6.61 |
| CHEMBL4647847 | — | EC50 | = | 303.0 | nM | 6.52 |
| CHEMBL4646025 | — | EC50 | = | 332.0 | nM | 6.48 |
| CHEMBL4640211 | — | EC50 | = | 548.0 | nM | 6.26 |
| CHEMBL4638592 | — | EC50 | = | 711.0 | nM | 6.15 |
| CHEMBL4648719 | — | EC50 | = | 766.0 | nM | 6.12 |
| CHEMBL4633558 | — | EC50 | = | 777.0 | nM | 6.11 |
| CHEMBL4633134 | — | EC50 | = | 826.0 | nM | 6.08 |
| CHEMBL4646039 | — | EC50 | = | 823.0 | nM | 6.08 |
| CHEMBL4642259 | — | EC50 | = | 861.0 | nM | 6.07 |
| CHEMBL4638605 | — | EC50 | = | 928.0 | nM | 6.03 |
| CHEMBL4634003 | — | EC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4641107 | — | EC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4634760 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4644181 | — | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4640452 | — | EC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4634268 | — | EC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL4635233 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4637613 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4638190 | — | EC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4648266 | — | EC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4636645 | — | EC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4646254 | — | EC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4635679 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL4637665 | — | EC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL4641851 | — | EC50 | - | — | - |