Assay Detail
Functional
CHEMBL4621655
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Cytotoxicity against human SF295 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter 96 aqueous one solution assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SF-295 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Characterization of TnmH as an <i>O</i>-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.23 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636420 | — | — | 1 | 9.35 |
| CHEMBL4648960 | — | — | 1 | 8.96 |
| CHEMBL4635291 | — | — | 1 | 8.55 |
| CHEMBL4633528 | — | — | 1 | 8.40 |
| CHEMBL4634658 | — | — | 1 | 7.68 |
| CHEMBL4639420 | — | — | 1 | 7.35 |
| CHEMBL4634930 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636420 | — | EC50 | = | 0.45 | nM | 9.35 |
| CHEMBL4648960 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4635291 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4633528 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4634658 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4639420 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4634930 | — | EC50 | = | 51.0 | nM | 7.29 |