Assay Detail
Binding
CHEMBL4621660
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Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysis
18
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 4.31 | 4.47 |
| IC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 4.47 |
| CHEMBL121772 | — | — | 1 | 4.32 |
| CHEMBL686 | MEFENAMIC ACID | 4.0 | 1 | 4.14 |
| CHEMBL54976 | TRYPTOPHAN | 4.0 | 2 | - |
| CHEMBL292303 | D-TRYPTOPHAN | — | 1 | - |
| CHEMBL461 | HIPPURIC ACID | — | 1 | - |
| CHEMBL622 | ETODOLAC | 4.0 | 1 | - |
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | — | 1 | - |
| CHEMBL277522 | FENBUFEN | 2.0 | 1 | - |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | - |
| CHEMBL154 | NAPROXEN | 4.0 | 1 | - |
| CHEMBL1618254 | — | — | 1 | - |
| CHEMBL3278332 | — | — | 1 | - |
| CHEMBL1233987 | DIAMINOPYRIMIDINE | — | 1 | - |
| CHEMBL170988 | PHENFORMIN | 4.0 | 1 | - |
| CHEMBL1431 | METFORMIN | 4.0 | 1 | - |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL898 | DIFLUNISAL | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL121772 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL686 | MEFENAMIC ACID | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL54976 | TRYPTOPHAN | Ki | = | 2800000.0 | nM | - |
| CHEMBL54976 | TRYPTOPHAN | IC50 | = | 6500000.0 | nM | - |
| CHEMBL292303 | D-TRYPTOPHAN | Ki | = | 880000.0 | nM | - |
| CHEMBL461 | HIPPURIC ACID | Ki | = | 17000000.0 | nM | - |
| CHEMBL622 | ETODOLAC | Ki | = | 1800000.0 | nM | - |
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | Ki | = | 810000.0 | nM | - |
| CHEMBL277522 | FENBUFEN | Ki | = | 360000.0 | nM | - |
| CHEMBL521 | IBUPROFEN | Ki | = | 560000.0 | nM | - |
| CHEMBL154 | NAPROXEN | Ki | = | 7000000.0 | nM | - |
| CHEMBL1618254 | — | Ki | = | 3400000.0 | nM | - |
| CHEMBL3278332 | — | Ki | = | 180000.0 | nM | - |
| CHEMBL1233987 | DIAMINOPYRIMIDINE | Ki | = | 180000.0 | nM | - |
| CHEMBL170988 | PHENFORMIN | Ki | = | 140000.0 | nM | - |
| CHEMBL1431 | METFORMIN | Ki | = | 18000000.0 | nM | - |
| CHEMBL139 | DICLOFENAC | Ki | = | 160000.0 | nM | - |