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Assay Detail

CHEMBL4621696

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human PD1/PDL1 protein-protein interaction by HTRF assay
ChEMBL ↗
87
Total Activities
87
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Discovery of Novel Resorcinol Dibenzyl Ethers Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction as Potential Anticancer Agents.
Cheng B, Ren Y, Niu X, Wang W, Wang S, Tu Y, Liu S, Wang J, Yang D, Liao G, Chen J.
J Med Chem (2020) 63 : 8338 -8358
PubMed 32667799 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 87 7.01 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4646293 — — 1 8.10
CHEMBL4638650 — — 1 8.10
CHEMBL4646486 — — 1 8.07
CHEMBL4635932 — — 1 8.05
CHEMBL4071326 — — 1 8.00
CHEMBL4646667 — — 1 7.96
CHEMBL4639202 — — 1 7.90
CHEMBL4646568 — — 1 7.89
CHEMBL4645569 — — 1 7.85
CHEMBL4640374 — — 1 7.84
CHEMBL4648149 — — 1 7.83
CHEMBL4641441 — — 1 7.82
CHEMBL4639656 — — 1 7.78
CHEMBL4648618 — — 1 7.60
CHEMBL4637912 — — 1 7.58
CHEMBL4644097 — — 1 7.56
CHEMBL4648624 — — 1 7.52
CHEMBL4641122 — — 1 7.51
CHEMBL4639047 — — 1 7.25
CHEMBL4089730 — — 1 7.21
CHEMBL4649236 — — 1 6.65
CHEMBL4646181 — — 1 6.63
CHEMBL4633433 — — 1 6.39
CHEMBL4641485 — — 1 6.39
CHEMBL4648825 — — 1 6.15
CHEMBL4646794 — — 1 5.85
CHEMBL4643467 — — 1 5.28
CHEMBL4644165 — — 1 4.84
CHEMBL4644681 — — 1 4.84
CHEMBL4640380 — — 1 4.71

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4646293 — IC50 = 7.9 nM 8.10
CHEMBL4638650 — IC50 = 8.0 nM 8.10
CHEMBL4646486 — IC50 = 8.5 nM 8.07
CHEMBL4635932 — IC50 = 9.0 nM 8.05
CHEMBL4071326 — IC50 = 10.1 nM 8.00
CHEMBL4646667 — IC50 = 11.1 nM 7.96
CHEMBL4639202 — IC50 = 12.5 nM 7.90
CHEMBL4646568 — IC50 = 12.9 nM 7.89
CHEMBL4645569 — IC50 = 14.1 nM 7.85
CHEMBL4640374 — IC50 = 14.5 nM 7.84
CHEMBL4648149 — IC50 = 14.9 nM 7.83
CHEMBL4641441 — IC50 = 15.2 nM 7.82
CHEMBL4639656 — IC50 = 16.7 nM 7.78
CHEMBL4648618 — IC50 = 25.2 nM 7.60
CHEMBL4637912 — IC50 = 26.3 nM 7.58
CHEMBL4644097 — IC50 = 27.5 nM 7.56
CHEMBL4648624 — IC50 = 30.4 nM 7.52
CHEMBL4641122 — IC50 = 31.2 nM 7.51
CHEMBL4639047 — IC50 = 55.9 nM 7.25
CHEMBL4089730 — IC50 = 61.1 nM 7.21
CHEMBL4649236 — IC50 = 224.8 nM 6.65
CHEMBL4646181 — IC50 = 232.9 nM 6.63
CHEMBL4633433 — IC50 = 407.5 nM 6.39
CHEMBL4641485 — IC50 = 408.7 nM 6.39
CHEMBL4648825 — IC50 = 710.5 nM 6.15
CHEMBL4646794 — IC50 = 1400.0 nM 5.85
CHEMBL4643467 — IC50 = 5300.0 nM 5.28
CHEMBL4644165 — IC50 = 14400.0 nM 4.84
CHEMBL4644681 — IC50 = 14600.0 nM 4.84
CHEMBL4640380 — IC50 = 19300.0 nM 4.71
CHEMBL4637393 — IC50 = 96600.0 nM 4.01
CHEMBL4638444 — IC50 > 100.0 nM -
CHEMBL1535342 APIIN IC50 > 100000.0 nM -
CHEMBL252915 SESAMIN IC50 > 100000.0 nM -
CHEMBL4639528 — IC50 > 20000.0 nM -
CHEMBL4637935 — IC50 > 10000.0 nM -
CHEMBL4649775 — IC50 > 100.0 nM -
CHEMBL4649522 — IC50 > 100.0 nM -
CHEMBL4637536 — IC50 > 100.0 nM -
CHEMBL4640901 — IC50 >= 10.0 nM -
CHEMBL4638714 — IC50 >= 10.0 nM -
CHEMBL4646151 — IC50 > 100.0 nM -
CHEMBL4646312 — IC50 > 100.0 nM -
CHEMBL4637463 — IC50 >= 10.0 nM -
CHEMBL4641838 — IC50 > 100.0 nM -
CHEMBL4639895 — IC50 > 100.0 nM -
CHEMBL4634811 — IC50 > 100.0 nM -
CHEMBL4642001 — IC50 >= 10.0 nM -
CHEMBL4648505 — IC50 >= 10.0 nM -
CHEMBL4640118 — IC50 > 20000.0 nM -