Assay Detail
Binding
CHEMBL4621699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PD1/PDL1 protein-protein interaction in human PBMC-derived CD3-positive T cells co-cultured with human Hep3B cells expressing human PDL1/OS-8 assessed as increase in IFNgamma secretion measured after 72 hrs by ELISA
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of Novel Resorcinol Dibenzyl Ethers Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction as Potential Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 1 | - | - |
| EC50 | 1 | 5.52 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639202 | — | — | 2 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639202 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4639202 | — | Inhibition | - | % | - |