Assay Detail
Functional
CHEMBL4622004
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against VSVG pseudotyped HIV1 infected in HEK293 cells preincubated for 3 hrs followed by compound washout and subsequent compound redosing and measured after 72 hrs by luciferase reporter gene based assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Mechanistic Insight into Antiretroviral Potency of 2'-Deoxy-2'-β-fluoro-4'-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.16 | 10.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519846 | RO-0622 | 3.0 | 1 | 10.20 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 6.52 |
| CHEMBL4641097 | — | — | 1 | 6.16 |
| CHEMBL4638873 | — | — | 1 | 6.16 |
| CHEMBL4639404 | — | — | 1 | 6.10 |
| CHEMBL4637117 | — | — | 1 | 5.89 |
| CHEMBL4637615 | — | — | 1 | 5.28 |
| CHEMBL4642407 | — | — | 1 | 5.24 |
| CHEMBL3581775 | — | — | 1 | 5.17 |
| CHEMBL3581782 | — | — | 1 | 4.89 |
| CHEMBL3581776 | — | — | 1 | - |
| CHEMBL3581781 | — | — | 1 | - |
| CHEMBL3581783 | — | — | 1 | - |
| CHEMBL3581784 | — | — | 1 | - |
| CHEMBL4642213 | — | — | 1 | - |
| CHEMBL4649375 | — | — | 1 | - |
| CHEMBL4633189 | — | — | 1 | - |
| CHEMBL4645018 | — | — | 1 | - |
| CHEMBL4640976 | — | — | 1 | - |
| CHEMBL4649070 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519846 | RO-0622 | EC50 | = | 0.063 | nM | 10.20 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4641097 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4638873 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4639404 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4637117 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4637615 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4642407 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3581775 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3581782 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3581776 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3581781 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3581783 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3581784 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4642213 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4649375 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4633189 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4645018 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4640976 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4649070 | — | EC50 | > | 10000.0 | nM | - |