Assay Detail
Binding
CHEMBL4622628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant AKR1C1 (unknown origin) assessed as reduction in S-tetralol-induced dehydrogenase activity by measuring NADPH level
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C1 (CHEMBL5905) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.22 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4644092 | — | — | 1 | 5.22 |
| CHEMBL4640154 | — | — | 1 | - |
| CHEMBL4646593 | — | — | 1 | - |
| CHEMBL4648793 | — | — | 1 | - |
| CHEMBL4639417 | — | — | 1 | - |
| CHEMBL4640248 | — | — | 1 | - |
| CHEMBL4634960 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4644092 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4640154 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4646593 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4648793 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4639417 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4640248 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4634960 | — | IC50 | > | 10000.0 | nM | - |