Assay Detail
Functional
CHEMBL4622710
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Vasodilatory activity in Wistar albino rat thoracic aorta assessed as relaxation of precontracted thoracic aorta stretched under passive tension
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of Novel Rho-Kinase-II Inhibitors with Vasodilatory Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.06 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635281 | — | — | 1 | 8.08 |
| CHEMBL4634858 | — | — | 1 | 8.07 |
| CHEMBL4633684 | — | — | 1 | 8.05 |
| CHEMBL559147 | Y-27632 | — | 1 | 8.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635281 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4634858 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4633684 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL559147 | Y-27632 | EC50 | = | 9.5 | nM | 8.02 |