Assay Detail
Binding
CHEMBL4622737
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Antagonist activity at human UT receptor expressed in HEK293 cells using Na [125I] incubated for 2 hrs by gamma counting method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Insights into the Molecular Determinants Involved in Urocontrin and Urocontrin A Action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.73 | 8.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635039 | — | — | 1 | 8.61 |
| CHEMBL4642307 | — | — | 1 | 8.50 |
| CHEMBL3104471 | — | — | 1 | 8.29 |
| CHEMBL4638346 | — | — | 1 | 8.10 |
| CHEMBL4643905 | — | — | 1 | 7.92 |
| CHEMBL4633010 | — | — | 1 | 7.44 |
| CHEMBL4638745 | — | — | 1 | 6.99 |
| CHEMBL4642313 | — | — | 1 | 6.87 |
| CHEMBL4635150 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635039 | — | IC50 | = | 2.455 | nM | 8.61 |
| CHEMBL4642307 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL3104471 | — | IC50 | = | 5.129 | nM | 8.29 |
| CHEMBL4638346 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL4643905 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL4633010 | — | IC50 | = | 36.31 | nM | 7.44 |
| CHEMBL4638745 | — | IC50 | = | 102.33 | nM | 6.99 |
| CHEMBL4642313 | — | IC50 | = | 134.9 | nM | 6.87 |
| CHEMBL4635150 | — | IC50 | = | 154.88 | nM | 6.81 |