Assay Detail
Binding
CHEMBL4623091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mu-calpain in porcine erythrocyte using Suc-Leu-Tyr-AMC as substrate by microtiter plate assay based Dixon plot analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Cell Type | Erythrocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antiproliferative activity of sulfonamide-based peptidomimetic calpain inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.67 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647187 | — | — | 1 | 8.05 |
| CHEMBL286722 | — | — | 1 | 8.00 |
| CHEMBL4642092 | — | — | 1 | 7.85 |
| CHEMBL4646991 | — | — | 1 | 7.80 |
| CHEMBL4642290 | — | — | 1 | 7.75 |
| CHEMBL4640485 | — | — | 1 | 6.56 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647187 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL286722 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4642092 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4646991 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4642290 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL4640485 | — | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL428647 | PACLITAXEL | Ki | - | — | - |