Assay Detail
Binding
CHEMBL4623363
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC3 (unknown origin)
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 8.82 | 10.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4649205 | — | — | 1 | 10.03 |
| CHEMBL4644038 | — | — | 1 | 9.74 |
| CHEMBL4642518 | — | — | 1 | 9.72 |
| CHEMBL4638264 | — | — | 1 | 9.55 |
| CHEMBL4637357 | — | — | 1 | 9.47 |
| CHEMBL4642023 | — | — | 1 | 9.47 |
| CHEMBL4648704 | — | — | 1 | 9.22 |
| CHEMBL4639206 | — | — | 1 | 9.11 |
| CHEMBL4638976 | — | — | 1 | 9.10 |
| CHEMBL4638330 | — | — | 1 | 9.10 |
| CHEMBL4644118 | — | — | 1 | 9.05 |
| CHEMBL4641343 | — | — | 1 | 8.92 |
| CHEMBL4634829 | — | — | 1 | 8.92 |
| CHEMBL4633758 | — | — | 1 | 8.92 |
| CHEMBL4632432 | — | — | 1 | 8.82 |
| CHEMBL4637745 | — | — | 1 | 8.82 |
| CHEMBL4646582 | — | — | 1 | 8.82 |
| CHEMBL4636652 | — | — | 1 | 8.82 |
| CHEMBL4640923 | — | — | 1 | 8.80 |
| CHEMBL4647014 | — | — | 1 | 8.77 |
| CHEMBL4640939 | — | — | 1 | 8.77 |
| CHEMBL4645468 | — | — | 1 | 8.74 |
| CHEMBL4644387 | — | — | 1 | 8.68 |
| CHEMBL4649561 | — | — | 1 | 8.68 |
| CHEMBL4637397 | — | — | 1 | 8.68 |
| CHEMBL4649628 | — | — | 1 | 8.60 |
| CHEMBL4636123 | — | — | 1 | 8.59 |
| CHEMBL4641048 | — | — | 1 | 8.55 |
| CHEMBL4643947 | — | — | 1 | 8.51 |
| CHEMBL4645863 | — | — | 1 | 8.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4649205 | — | IC50 | = | 0.093 | nM | 10.03 |
| CHEMBL4644038 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL4642518 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4638264 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL4637357 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL4642023 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL4648704 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4639206 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL4638976 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4638330 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4644118 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4641343 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4634829 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4633758 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4636652 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4632432 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4646582 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4637745 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4640923 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4640939 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4647014 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4645468 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4644387 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4649561 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4637397 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4649628 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4636123 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4641048 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4643947 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4645863 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4645825 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4644657 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4632614 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL4635878 | — | IC50 | = | 20.4 | nM | 7.69 |
| CHEMBL4641299 | — | IC50 | = | 31.9 | nM | 7.50 |
| CHEMBL4646915 | — | IC50 | < | 1.5 | nM | - |