Assay Detail
Functional
CHEMBL4623366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reactivation of HIV latency infected in human 2C4 cells in presence of 0.1 % NHS by luciferase reporter gene assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 6.86 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4649205 | — | — | 1 | 7.82 |
| CHEMBL4637357 | — | — | 1 | 7.58 |
| CHEMBL4642518 | — | — | 1 | 7.58 |
| CHEMBL4644038 | — | — | 1 | 7.50 |
| CHEMBL4642023 | — | — | 1 | 7.44 |
| CHEMBL4638264 | — | — | 1 | 7.37 |
| CHEMBL4639206 | — | — | 1 | 7.21 |
| CHEMBL4644118 | — | — | 1 | 7.14 |
| CHEMBL4634829 | — | — | 1 | 7.14 |
| CHEMBL4638330 | — | — | 1 | 7.13 |
| CHEMBL4644387 | — | — | 1 | 7.13 |
| CHEMBL4643947 | — | — | 1 | 7.11 |
| CHEMBL4632614 | — | — | 1 | 7.09 |
| CHEMBL4637745 | — | — | 1 | 7.07 |
| CHEMBL2448576 | — | — | 1 | 6.96 |
| CHEMBL4648704 | — | — | 1 | 6.96 |
| CHEMBL4647014 | — | — | 1 | 6.95 |
| CHEMBL4632432 | — | — | 1 | 6.95 |
| CHEMBL4633758 | — | — | 1 | 6.90 |
| CHEMBL4638976 | — | — | 1 | 6.89 |
| CHEMBL4641343 | — | — | 1 | 6.89 |
| CHEMBL4640939 | — | — | 1 | 6.81 |
| CHEMBL4636652 | — | — | 1 | 6.81 |
| CHEMBL4646582 | — | — | 1 | 6.79 |
| CHEMBL4649628 | — | — | 1 | 6.79 |
| CHEMBL4646915 | — | — | 1 | 6.71 |
| CHEMBL4649561 | — | — | 1 | 6.63 |
| CHEMBL4637397 | — | — | 1 | 6.59 |
| CHEMBL4645468 | — | — | 1 | 6.58 |
| CHEMBL4641048 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4649205 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4637357 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4642518 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4644038 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4642023 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4638264 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4639206 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4644118 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4634829 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4638330 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4644387 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4643947 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4632614 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4637745 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4648704 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL2448576 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4647014 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4632432 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4633758 | — | EC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4638976 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4641343 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4640939 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4636652 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL4646582 | — | EC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4649628 | — | EC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4646915 | — | EC50 | = | 194.0 | nM | 6.71 |
| CHEMBL4649561 | — | EC50 | = | 234.0 | nM | 6.63 |
| CHEMBL4637397 | — | EC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4645468 | — | EC50 | = | 261.0 | nM | 6.58 |
| CHEMBL4641048 | — | EC50 | = | 309.0 | nM | 6.51 |
| CHEMBL4640923 | — | EC50 | = | 339.0 | nM | 6.47 |
| CHEMBL4645863 | — | EC50 | = | 441.0 | nM | 6.36 |
| CHEMBL4645825 | — | EC50 | = | 647.0 | nM | 6.19 |
| CHEMBL4644657 | — | EC50 | = | 689.0 | nM | 6.16 |
| CHEMBL4635878 | — | EC50 | = | 1232.0 | nM | 5.91 |
| CHEMBL4636123 | — | EC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4641299 | — | EC50 | = | 1622.0 | nM | 5.79 |
| CHEMBL3286732 | — | EC50 | - | — | - |