Assay Detail
Functional
CHEMBL4623367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reactivation of HIV latency infected in human 2C4 cells in presence of 5 % NHS by luciferase reporter gene assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 6.29 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4649205 | — | — | 1 | 7.52 |
| CHEMBL4644038 | — | — | 1 | 7.24 |
| CHEMBL4637357 | — | — | 1 | 7.24 |
| CHEMBL4642023 | — | — | 1 | 7.22 |
| CHEMBL4642518 | — | — | 1 | 7.08 |
| CHEMBL4638264 | — | — | 1 | 6.96 |
| CHEMBL4648704 | — | — | 1 | 6.82 |
| CHEMBL4644387 | — | — | 1 | 6.76 |
| CHEMBL4647014 | — | — | 1 | 6.75 |
| CHEMBL4644118 | — | — | 1 | 6.63 |
| CHEMBL4639206 | — | — | 1 | 6.56 |
| CHEMBL4638330 | — | — | 1 | 6.54 |
| CHEMBL4649628 | — | — | 1 | 6.51 |
| CHEMBL4646915 | — | — | 1 | 6.51 |
| CHEMBL4632614 | — | — | 1 | 6.49 |
| CHEMBL4634829 | — | — | 1 | 6.49 |
| CHEMBL4643947 | — | — | 1 | 6.46 |
| CHEMBL2448576 | — | — | 1 | 6.32 |
| CHEMBL4636652 | — | — | 1 | 6.20 |
| CHEMBL4644657 | — | — | 1 | 6.16 |
| CHEMBL4637745 | — | — | 1 | 6.16 |
| CHEMBL4646582 | — | — | 1 | 6.14 |
| CHEMBL4632432 | — | — | 1 | 6.14 |
| CHEMBL4638976 | — | — | 1 | 6.09 |
| CHEMBL4641343 | — | — | 1 | 6.08 |
| CHEMBL4640939 | — | — | 1 | 6.05 |
| CHEMBL4633758 | — | — | 1 | 6.03 |
| CHEMBL4637397 | — | — | 1 | 6.00 |
| CHEMBL4645863 | — | — | 1 | 5.94 |
| CHEMBL4641048 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4649205 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4644038 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4637357 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4642023 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4642518 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4638264 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4648704 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL4644387 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL4647014 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4644118 | — | EC50 | = | 232.0 | nM | 6.63 |
| CHEMBL4639206 | — | EC50 | = | 277.0 | nM | 6.56 |
| CHEMBL4638330 | — | EC50 | = | 287.0 | nM | 6.54 |
| CHEMBL4649628 | — | EC50 | = | 309.0 | nM | 6.51 |
| CHEMBL4646915 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4634829 | — | EC50 | = | 321.0 | nM | 6.49 |
| CHEMBL4632614 | — | EC50 | = | 324.0 | nM | 6.49 |
| CHEMBL4643947 | — | EC50 | = | 343.0 | nM | 6.46 |
| CHEMBL2448576 | — | EC50 | = | 477.0 | nM | 6.32 |
| CHEMBL4636652 | — | EC50 | = | 633.0 | nM | 6.20 |
| CHEMBL4644657 | — | EC50 | = | 691.0 | nM | 6.16 |
| CHEMBL4637745 | — | EC50 | = | 687.0 | nM | 6.16 |
| CHEMBL4646582 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4632432 | — | EC50 | = | 719.0 | nM | 6.14 |
| CHEMBL4638976 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4641343 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4640939 | — | EC50 | = | 895.0 | nM | 6.05 |
| CHEMBL4633758 | — | EC50 | = | 941.0 | nM | 6.03 |
| CHEMBL4637397 | — | EC50 | = | 1008.0 | nM | 6.00 |
| CHEMBL4641048 | — | EC50 | = | 1149.0 | nM | 5.94 |
| CHEMBL4645468 | — | EC50 | = | 1142.0 | nM | 5.94 |
| CHEMBL4645863 | — | EC50 | = | 1144.0 | nM | 5.94 |
| CHEMBL4640923 | — | EC50 | = | 1366.0 | nM | 5.87 |
| CHEMBL4649561 | — | EC50 | = | 1786.0 | nM | 5.75 |
| CHEMBL4635878 | — | EC50 | = | 1877.0 | nM | 5.73 |
| CHEMBL4641299 | — | EC50 | = | 2583.0 | nM | 5.59 |
| CHEMBL4645825 | — | EC50 | = | 5036.0 | nM | 5.30 |
| CHEMBL4636123 | — | EC50 | = | 9848.0 | nM | 5.01 |
| CHEMBL3286732 | — | EC50 | = | 15690.0 | nM | 4.80 |