Assay Detail
Functional
CHEMBL4623595
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Antiproliferative activity against human MKN45 cells overexpressing c-MET assessed as reduction in cell proliferation
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of quinoxaline derivatives as specific c-Met kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.78 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 8.04 |
| CHEMBL4640560 | — | — | 1 | 7.11 |
| CHEMBL4645582 | — | — | 1 | 6.95 |
| CHEMBL4638210 | — | — | 1 | 6.94 |
| CHEMBL4638327 | — | — | 1 | 6.93 |
| CHEMBL4649193 | — | — | 1 | 6.88 |
| CHEMBL4644985 | — | — | 1 | 6.76 |
| CHEMBL4636429 | — | — | 1 | 6.71 |
| CHEMBL4635560 | — | — | 1 | 6.64 |
| CHEMBL4648551 | — | — | 1 | 6.61 |
| CHEMBL4648693 | — | — | 1 | 6.60 |
| CHEMBL4646769 | — | — | 1 | 6.51 |
| CHEMBL4642284 | — | — | 1 | 6.13 |
| CHEMBL4641413 | — | — | 1 | 6.10 |
| CHEMBL4643041 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4640560 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4645582 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4638210 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4638327 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4649193 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL4644985 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL4636429 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL4635560 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL4648551 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL4648693 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL4646769 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL4642284 | — | IC50 | = | 735.0 | nM | 6.13 |
| CHEMBL4641413 | — | IC50 | = | 797.0 | nM | 6.10 |
| CHEMBL4643041 | — | IC50 | - | — | - |