Compound Detail
CHEMBL4648693
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CC(=O)OCCn1cc(-c2cnc3ccc(O[C@H](C)c4c(Cl)ccc(F)c4Cl)cc3n2)cn1
Basic Information
| ChEMBL ID | CHEMBL4648693 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UOIDJPSWNUUWFG-CYBMUJFWSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
489.3
MW (Da)
5.64
ALogP
7
HBA
0
HBD
79.1
PSA (Ų)
0.25
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| MKN-45 CHEMBL614354 | IC50 | 6.6 | 6.6 | 252.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 12.0 | nM | 7.92 | Inhibition of c-Met (unknown origin) by ADP-Glo kinase assay | 32371098 |
| MKN-45 | IC50 | = | 252.0 | nM | 6.6 | Antiproliferative activity against human MKN45 cells overexpressing c-MET assess... | 32371098 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32371098 | 10.1016/j.bmcl.2020.127189 | Hepatocyte growth factor receptor | 1 |
| 32371098 | 10.1016/j.bmcl.2020.127189 | MKN-45 | 1 |
Data from ChEMBL 36 via Core Engine