Assay Detail
Binding
CHEMBL4623596
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Inhibition of c-Met (unknown origin) by ADP-Glo kinase assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of quinoxaline derivatives as specific c-Met kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.95 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 9.05 |
| CHEMBL4645582 | — | — | 1 | 8.52 |
| CHEMBL4649193 | — | — | 1 | 8.40 |
| CHEMBL4646769 | — | — | 1 | 8.30 |
| CHEMBL4644985 | — | — | 1 | 8.22 |
| CHEMBL4638327 | — | — | 1 | 8.22 |
| CHEMBL4648693 | — | — | 1 | 7.92 |
| CHEMBL4638210 | — | — | 1 | 7.92 |
| CHEMBL4642284 | — | — | 1 | 7.85 |
| CHEMBL4636429 | — | — | 1 | 7.85 |
| CHEMBL4648551 | — | — | 1 | 7.77 |
| CHEMBL4635560 | — | — | 1 | 7.75 |
| CHEMBL4640560 | — | — | 1 | 7.50 |
| CHEMBL4641413 | — | — | 1 | 7.04 |
| CHEMBL4643041 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4645582 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4649193 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4646769 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4644985 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4638327 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4648693 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4638210 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4642284 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4636429 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4648551 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4635560 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4640560 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4641413 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4643041 | — | IC50 | = | 126.0 | nM | 6.90 |