Assay Detail
Functional
CHEMBL4624828
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Antiproliferation activity against human U87MG cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity, and in vivo antitumor activity study of parthenolide semicarbazones and thiosemicarbazones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.43 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.42 |
| CHEMBL4633371 | — | — | 1 | 5.83 |
| CHEMBL4638757 | — | — | 1 | 5.64 |
| CHEMBL4634484 | — | — | 1 | 5.61 |
| CHEMBL4647017 | — | — | 1 | 5.60 |
| CHEMBL4643037 | — | — | 1 | 5.57 |
| CHEMBL4641878 | — | — | 1 | 5.55 |
| CHEMBL4645051 | — | — | 1 | 5.52 |
| CHEMBL4649423 | — | — | 1 | 5.50 |
| CHEMBL4644332 | — | — | 1 | 5.49 |
| CHEMBL4636438 | — | — | 1 | 5.36 |
| CHEMBL4649419 | — | — | 1 | 5.34 |
| CHEMBL4646810 | — | — | 1 | 5.32 |
| CHEMBL4641992 | — | — | 1 | 5.26 |
| CHEMBL477923 | — | — | 1 | 5.24 |
| CHEMBL4642396 | — | — | 1 | 5.22 |
| CHEMBL561183 | — | — | 1 | 5.13 |
| CHEMBL4646929 | — | — | 1 | 5.01 |
| CHEMBL4637814 | — | — | 1 | 4.85 |
| CHEMBL4647700 | — | — | 1 | 4.84 |
| CHEMBL4641440 | — | — | 1 | 4.83 |
| CHEMBL4633648 | — | — | 1 | 4.76 |
| CHEMBL4643992 | — | — | 1 | 4.76 |
| CHEMBL4634155 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL4633371 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4638757 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL4634484 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL4647017 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL4643037 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL4641878 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL4645051 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL4649423 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL4644332 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL4636438 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL4649419 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL4646810 | — | IC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL4641992 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL477923 | — | IC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL4642396 | — | IC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL561183 | — | IC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL4646929 | — | IC50 | = | 9750.0 | nM | 5.01 |
| CHEMBL4637814 | — | IC50 | = | 14020.0 | nM | 4.85 |
| CHEMBL4647700 | — | IC50 | = | 14550.0 | nM | 4.84 |
| CHEMBL4641440 | — | IC50 | = | 14740.0 | nM | 4.83 |
| CHEMBL4633648 | — | IC50 | = | 17290.0 | nM | 4.76 |
| CHEMBL4643992 | — | IC50 | = | 17160.0 | nM | 4.76 |
| CHEMBL4634155 | — | IC50 | = | 18740.0 | nM | 4.73 |