Assay Detail
Binding
CHEMBL4625229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Hi6-tagged deltaFOSB (unknown origin) expressed in insect cells interaction with TAMRA labeled 5'-GTCGGTGACTCAAAACA-3' AP1 oligonucleotide measured after 15 mins by fluorescence polarization assay
16
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.39 | 4.54 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1528814 | — | — | 1 | 4.54 |
| CHEMBL4640716 | — | — | 2 | 4.24 |
| CHEMBL4635546 | — | — | 1 | - |
| CHEMBL4634410 | — | — | 1 | - |
| CHEMBL4640911 | — | — | 1 | - |
| CHEMBL4642507 | — | — | 1 | - |
| CHEMBL4636518 | — | — | 1 | - |
| CHEMBL4646481 | — | — | 1 | - |
| CHEMBL4644096 | — | — | 1 | - |
| CHEMBL4648918 | — | — | 1 | - |
| CHEMBL4648459 | — | — | 1 | - |
| CHEMBL4638737 | — | — | 1 | - |
| CHEMBL4637145 | — | — | 1 | - |
| CHEMBL4648025 | — | — | 1 | - |
| CHEMBL4643910 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1528814 | — | IC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL4640716 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL4635546 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4634410 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4640911 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4642507 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4636518 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4646481 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4644096 | — | IC50 | - | — | - | |
| CHEMBL4648918 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4648459 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4638737 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4637145 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4648025 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4643910 | — | IC50 | - | — | - | |
| CHEMBL4640716 | — | Inhibition | - | % | - |