Compound Detail
CHEMBL4640716
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Basic Information
| ChEMBL ID | CHEMBL4640716 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IRVZACWCHIPXKH-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
352.4
MW (Da)
3.88
ALogP
5
HBA
1
HBD
52.6
PSA (Ų)
0.72
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein fosB/Transcription factor jun-D CHEMBL4630755 | IC50 | 4.25 | 4.25 | 55700.0 | 1 |
| Protein FosB CHEMBL4630821 | IC50 | 4.24 | 4.24 | 58000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein fosB/Transcription factor jun-D | IC50 | = | 55700.0 | nM | 4.25 | Inhibition of recombinant Hi6-tagged deltaFOSB (unknown origin)/His6-tagged JUND... | 32631520 |
| Protein FosB | IC50 | = | 58000.0 | nM | 4.24 | Inhibition of recombinant Hi6-tagged deltaFOSB (unknown origin) expressed in ins... | 32631520 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32631520 | 10.1016/j.bmcl.2020.127300 | Protein FosB | 2 |
| 32631520 | 10.1016/j.bmcl.2020.127300 | Protein fosB/Transcription factor jun-D | 2 |
Data from ChEMBL 36 via Core Engine