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Assay Detail

CHEMBL4626293

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of PTP1B (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis spectrophotometric method
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Highly Potent and Selective <i>N</i>-Aryl Oxamic Acid-Based Inhibitors for <i>Mycobacterium tuberculosis</i> Protein Tyrosine Phosphatase B.
Ruddraraju KV, Aggarwal D, Niu C, Baker EA, Zhang RY, Wu L, Zhang ZY.
J Med Chem (2020) 63 : 9212 -9227
PubMed 32787087 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 36 4.48 4.79

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4637373 1 4.79
CHEMBL4641106 1 4.56
CHEMBL4647377 1 4.53
CHEMBL4635765 1 4.41
CHEMBL4632818 1 4.35
CHEMBL4642395 1 4.21
CHEMBL4638797 1 -
CHEMBL4645770 1 -
CHEMBL4635310 1 -
CHEMBL4646506 1 -
CHEMBL4635176 1 -
CHEMBL4649291 1 -
CHEMBL4649843 1 -
CHEMBL4644874 1 -
CHEMBL4649071 1 -
CHEMBL4642274 1 -
CHEMBL4637459 1 -
CHEMBL4649838 1 -
CHEMBL4649025 1 -
CHEMBL4633719 1 -
CHEMBL4649133 1 -
CHEMBL3248231 1 -
CHEMBL4647989 1 -
CHEMBL4633441 1 -
CHEMBL4632681 1 -
CHEMBL4641525 1 -
CHEMBL4649112 1 -
CHEMBL4638011 1 -
CHEMBL4636634 1 -
CHEMBL4647367 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4637373 IC50 = 16400.0 nM 4.79
CHEMBL4641106 IC50 = 27400.0 nM 4.56
CHEMBL4647377 IC50 = 29500.0 nM 4.53
CHEMBL4635765 IC50 = 38900.0 nM 4.41
CHEMBL4632818 IC50 = 45100.0 nM 4.35
CHEMBL4642395 IC50 = 62000.0 nM 4.21
CHEMBL4635176 IC50 > 50000.0 nM -
CHEMBL4633958 IC50 > 100000.0 nM -
CHEMBL4649291 IC50 > 50000.0 nM -
CHEMBL4649843 IC50 > 50000.0 nM -
CHEMBL4644874 IC50 > 50000.0 nM -
CHEMBL4649071 IC50 > 50000.0 nM -
CHEMBL4642274 IC50 > 50000.0 nM -
CHEMBL4637459 IC50 > 50000.0 nM -
CHEMBL4649838 IC50 > 50000.0 nM -
CHEMBL4645770 IC50 > 50000.0 nM -
CHEMBL4636357 IC50 > 100000.0 nM -
CHEMBL4640123 IC50 > 50000.0 nM -
CHEMBL4632655 IC50 > 50000.0 nM -
CHEMBL4636548 IC50 > 50000.0 nM -
CHEMBL4647032 IC50 > 50000.0 nM -
CHEMBL4646506 IC50 > 50000.0 nM -
CHEMBL4635310 IC50 > 100000.0 nM -
CHEMBL4638797 IC50 > 100000.0 nM -
CHEMBL4649025 IC50 > 100000.0 nM -
CHEMBL4633719 IC50 > 100000.0 nM -
CHEMBL4649133 IC50 > 100000.0 nM -
CHEMBL3248231 IC50 > 100000.0 nM -
CHEMBL4647989 IC50 > 30000.0 nM -
CHEMBL4633441 IC50 > 30000.0 nM -
CHEMBL4632681 IC50 > 30000.0 nM -
CHEMBL4641525 IC50 > 30000.0 nM -
CHEMBL4649112 IC50 > 30000.0 nM -
CHEMBL4638011 IC50 > 30000.0 nM -
CHEMBL4636634 IC50 > 100000.0 nM -
CHEMBL4647367 IC50 > 30000.0 nM -