Assay Detail
Binding
CHEMBL4626980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escherichia coli after 1 hr by TR-FRET assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.32 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635329 | — | — | 1 | 8.00 |
| CHEMBL2017291 | — | — | 1 | 7.60 |
| CHEMBL4639128 | GSK778 | — | 1 | 7.40 |
| CHEMBL4633643 | — | — | 1 | 7.30 |
| CHEMBL4639924 | — | — | 1 | 7.10 |
| CHEMBL4640166 | — | — | 1 | 6.60 |
| CHEMBL4635126 | — | — | 1 | 6.30 |
| CHEMBL4641363 | — | — | 1 | 6.30 |
| CHEMBL4641414 | — | — | 1 | 6.20 |
| CHEMBL4642291 | — | — | 1 | 6.10 |
| CHEMBL4648188 | — | — | 1 | 6.10 |
| CHEMBL4644512 | — | — | 1 | 6.10 |
| CHEMBL4643720 | — | — | 1 | 6.00 |
| CHEMBL4633358 | — | — | 1 | 6.00 |
| CHEMBL4635194 | — | — | 1 | 5.90 |
| CHEMBL4640928 | — | — | 1 | 5.90 |
| CHEMBL4646732 | — | — | 1 | 5.70 |
| CHEMBL4637861 | — | — | 1 | 5.70 |
| CHEMBL4642458 | — | — | 1 | 5.20 |
| CHEMBL4639916 | — | — | 1 | 4.90 |
| CHEMBL4639591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635329 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2017291 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL4639128 | GSK778 | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL4633643 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL4639924 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4640166 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4635126 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4641363 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4641414 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4642291 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4648188 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4644512 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4643720 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4633358 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4635194 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4640928 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4646732 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4637861 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4642458 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4639916 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL4639591 | — | IC50 | > | 50118.72 | nM | - |