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Assay Detail

CHEMBL4627088

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and Antitumor Activity of C-7-Alkynylated and Arylated Pyrrolotriazine C-Ribonucleosides.
Li Q, Groaz E, Persoons L, Daelemans D, Herdewijn P.
ACS Med Chem Lett (2020) 11 : 1605 -1610
PubMed 32832030 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.71 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL388978 STAUROSPORINE 1 7.40
CHEMBL4640462 1 7.40
CHEMBL92 DOCETAXEL ANHYDROUS 4.0 1 7.30
CHEMBL4641965 1 6.70
CHEMBL4646493 1 6.40
CHEMBL4642282 1 6.30
CHEMBL4649297 1 5.70
CHEMBL4641079 1 4.43
CHEMBL4634483 1 4.42
CHEMBL4645792 1 4.32
CHEMBL4634881 1 4.17
CHEMBL4636054 1 4.00
CHEMBL4644331 1 -
CHEMBL4638439 1 -
CHEMBL4635716 1 -
CHEMBL4634224 1 -
CHEMBL4635032 1 -
CHEMBL4638455 1 -
CHEMBL4646082 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL388978 STAUROSPORINE IC50 = 40.0 nM 7.40
CHEMBL4640462 IC50 = 40.0 nM 7.40
CHEMBL92 DOCETAXEL ANHYDROUS IC50 = 50.0 nM 7.30
CHEMBL4641965 IC50 = 200.0 nM 6.70
CHEMBL4646493 IC50 = 400.0 nM 6.40
CHEMBL4642282 IC50 = 500.0 nM 6.30
CHEMBL4649297 IC50 = 2000.0 nM 5.70
CHEMBL4641079 IC50 = 37300.0 nM 4.43
CHEMBL4634483 IC50 = 37900.0 nM 4.42
CHEMBL4645792 IC50 = 48400.0 nM 4.32
CHEMBL4634881 IC50 = 68300.0 nM 4.17
CHEMBL4636054 IC50 = 99300.0 nM 4.00
CHEMBL4644331 IC50 > 100000.0 nM -
CHEMBL4638439 IC50 > 100000.0 nM -
CHEMBL4635716 IC50 > 100000.0 nM -
CHEMBL4634224 IC50 > 100000.0 nM -
CHEMBL4635032 IC50 > 100000.0 nM -
CHEMBL4638455 IC50 > 100000.0 nM -
CHEMBL4646082 IC50 > 100000.0 nM -