Assay Detail
Binding
CHEMBL4627148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GST-tagged tankyrase 2 autophosphorylation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Poly [ADP-ribose] polymerase tankyrase-2 (CHEMBL6154) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 4-Heteroarylcarbonyl-N-(phenyl or heteroaryl) Piperidine-1-carboxamides as Tankyrase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.56 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634919 | — | — | 1 | 9.72 |
| CHEMBL4632401 | — | — | 1 | 9.60 |
| CHEMBL4640008 | — | — | 1 | 9.59 |
| CHEMBL4643690 | — | — | 1 | 9.57 |
| CHEMBL4639702 | — | — | 1 | 9.54 |
| CHEMBL4645574 | — | — | 1 | 9.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634919 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4632401 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL4640008 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL4643690 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL4639702 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL4645574 | — | IC50 | = | 0.44 | nM | 9.36 |