Assay Detail
Binding
CHEMBL4627713
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK1/JAK3 in human PBMC cells assessed as reduction in IL2-induced IFNgamma production
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.30 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635876 | — | — | 1 | 8.10 |
| CHEMBL4634979 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635876 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL4634979 | — | IC50 | = | 316.23 | nM | 6.50 |