Assay Detail
Binding
CHEMBL4627757
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Displacement of [125I]MIP-1095 from PSMA in human PC3-PIP cells after 1 hr by gamma counter analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel radioiodinated PSMA targeting ligands for potential radiotherapy of prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.41 | 8.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636677 | — | — | 1 | 8.88 |
| CHEMBL4636963 | — | — | 1 | 8.70 |
| CHEMBL4649277 | — | — | 1 | 8.58 |
| CHEMBL456029 | MIP-1095 | 1.0 | 1 | 8.52 |
| CHEMBL4639640 | — | — | 1 | 8.45 |
| CHEMBL4648379 | — | — | 1 | 8.32 |
| CHEMBL4594280 | VIPIVOTIDE TETRAXETAN | 2.0 | 1 | 7.96 |
| CHEMBL4635514 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636677 | — | IC50 | = | 1.33 | nM | 8.88 |
| CHEMBL4636963 | — | IC50 | = | 1.99 | nM | 8.70 |
| CHEMBL4649277 | — | IC50 | = | 2.63 | nM | 8.58 |
| CHEMBL456029 | MIP-1095 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4639640 | — | IC50 | = | 3.52 | nM | 8.45 |
| CHEMBL4648379 | — | IC50 | = | 4.74 | nM | 8.32 |
| CHEMBL4594280 | VIPIVOTIDE TETRAXETAN | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL4635514 | — | IC50 | = | 13.0 | nM | 7.89 |