Compound Detail
CHEMBL4594280
VIPIVOTIDE TETRAXETAN 🧪 Phase II
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🧪 Phase II
O=C(O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CC[C@H](CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(=O)O)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL4594280 |
| Name | VIPIVOTIDE TETRAXETAN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | JBHPLHATEXGMQR-LFWIOBPJSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
6
Publications
5
Known Names
7
Indications
Molecular Properties
1042.2
MW (Da)
Drug Information
| Molecule Type | Protein |
| Chirality | Single Enantiomer |
Indications
Diagnostic Imaging Neoplasms Prostatic Neoplasms Prostatic Neoplasms Prostatic Neoplasms Prostatic Neoplasms Prostatic Neoplasms, Castration-Resistant
Activity Summary
IC50 1 meas. best 7.96
Ki 1 meas. best 8.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate carboxypeptidase 2 CHEMBL1892 | Ki | 8.63 | 8.63 | 2.3 | 1 |
| Glutamate carboxypeptidase 2 CHEMBL1892 | IC50 | 7.96 | 7.96 | 10.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate carboxypeptidase 2 | Ki | = | 2.34 | nM | 8.63 | Binding affinity to PSMA in human LNCaP cells after 45 mins in presence of 68Ga-... | 26878194 |
| Glutamate carboxypeptidase 2 | IC50 | = | 10.9 | nM | 7.96 | Displacement of [125I]MIP-1095 from PSMA in human PC3-PIP cells after 1 hr by ga... | 32001090 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26878194 | 10.1021/acs.jmedchem.5b01210 | ADMET | 5 |
| 26878194 | 10.1021/acs.jmedchem.5b01210 | Glutamate carboxypeptidase 2 | 3 |
| 26878194 | 10.1021/acs.jmedchem.5b01210 | No relevant target | 2 |
| 32001090 | 10.1016/j.bmc.2020.115319 | Glutamate carboxypeptidase 2 | 1 |
| 26878194 | 10.1021/acs.jmedchem.5b01210 | Unchecked | 1 |
| 38716576 | 10.1021/acs.jmedchem.4c00332 | Glutamate carboxypeptidase 2 | 1 |
Data from ChEMBL 36 via Core Engine