Assay Detail
Binding
CHEMBL4628152
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Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-based assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.24 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2142592 | TALADEGIB | 2.0 | 1 | 8.38 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 7.88 |
| CHEMBL4632598 | — | — | 1 | 7.47 |
| CHEMBL4644288 | — | — | 1 | 6.91 |
| CHEMBL4635021 | — | — | 1 | 6.54 |
| CHEMBL4639888 | — | — | 1 | 6.51 |
| CHEMBL4632537 | — | — | 1 | 6.25 |
| CHEMBL4645447 | — | — | 1 | 6.12 |
| CHEMBL4641704 | — | — | 1 | 5.88 |
| CHEMBL4646599 | — | — | 1 | 5.72 |
| CHEMBL4644469 | — | — | 1 | 5.36 |
| CHEMBL4647112 | — | — | 1 | 5.31 |
| CHEMBL4632758 | — | — | 1 | 5.16 |
| CHEMBL4649551 | — | — | 1 | 5.15 |
| CHEMBL4633504 | — | — | 1 | 5.03 |
| CHEMBL4642236 | — | — | 1 | - |
| CHEMBL4648312 | — | — | 1 | - |
| CHEMBL4642779 | — | — | 1 | - |
| CHEMBL4646912 | — | — | 1 | - |
| CHEMBL4639086 | — | — | 1 | - |
| CHEMBL4639103 | — | — | 1 | - |
| CHEMBL4641820 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2142592 | TALADEGIB | IC50 | = | 4.17 | nM | 8.38 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 13.06 | nM | 7.88 |
| CHEMBL4632598 | — | IC50 | = | 34.09 | nM | 7.47 |
| CHEMBL4644288 | — | IC50 | = | 123.4 | nM | 6.91 |
| CHEMBL4635021 | — | IC50 | = | 285.25 | nM | 6.54 |
| CHEMBL4639888 | — | IC50 | = | 308.7 | nM | 6.51 |
| CHEMBL4632537 | — | IC50 | = | 561.9 | nM | 6.25 |
| CHEMBL4645447 | — | IC50 | = | 754.05 | nM | 6.12 |
| CHEMBL4641704 | — | IC50 | = | 1328.0 | nM | 5.88 |
| CHEMBL4646599 | — | IC50 | = | 1909.5 | nM | 5.72 |
| CHEMBL4644469 | — | IC50 | = | 4365.5 | nM | 5.36 |
| CHEMBL4647112 | — | IC50 | = | 4858.0 | nM | 5.31 |
| CHEMBL4632758 | — | IC50 | = | 6864.0 | nM | 5.16 |
| CHEMBL4649551 | — | IC50 | = | 7117.0 | nM | 5.15 |
| CHEMBL4633504 | — | IC50 | = | 9369.5 | nM | 5.03 |
| CHEMBL4642236 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4648312 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4642779 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4646912 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4639086 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4639103 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4641820 | — | IC50 | > | 10000.0 | nM | - |