Assay Detail
Binding
CHEMBL4628255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Ezh1 (unknown origin) preincubated for 15 mins followed by addition of substrate measured after 1 hr by AlphaLISA assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase EZH1 (CHEMBL2189116) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Computational discovery and biological evaluation of novel inhibitors targeting histone-lysine N-methyltransferase SET7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.06 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55415 | SCUTELLAREIN | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55415 | SCUTELLAREIN | IC50 | = | 8770.0 | nM | 5.06 |