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Assay Detail

CHEMBL4628380

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Binding
Binding affinity to human D1 receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(1A) dopamine receptor (CHEMBL2056)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of C10 nitrogen-containing aporphines with dopamine D<sub>1</sub> versus D<sub>5</sub> receptor selectivity.
Karki A, Juarez R, Namballa HK, Alberts I, Harding WW.
Bioorg Med Chem Lett (2020) 30 : 127053 -127053
PubMed 32107165 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 6.51 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL8514 BUTACLAMOL 2.0 1 8.70
CHEMBL4633772 1 7.24
CHEMBL4645375 1 6.81
CHEMBL4637246 1 6.52
CHEMBL4636948 1 6.50
CHEMBL4638749 1 6.27
CHEMBL4639398 1 6.16
CHEMBL4636589 1 6.15
CHEMBL4646927 1 6.14
CHEMBL4637673 1 6.12
CHEMBL4649785 1 6.08
CHEMBL4636242 1 6.03
CHEMBL4636318 1 5.95

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL8514 BUTACLAMOL Ki = 2.0 nM 8.70
CHEMBL4633772 Ki = 58.0 nM 7.24
CHEMBL4645375 Ki = 155.0 nM 6.81
CHEMBL4637246 Ki = 301.0 nM 6.52
CHEMBL4636948 Ki = 316.0 nM 6.50
CHEMBL4638749 Ki = 536.0 nM 6.27
CHEMBL4639398 Ki = 691.0 nM 6.16
CHEMBL4636589 Ki = 709.0 nM 6.15
CHEMBL4646927 Ki = 726.0 nM 6.14
CHEMBL4637673 Ki = 756.0 nM 6.12
CHEMBL4649785 Ki = 830.0 nM 6.08
CHEMBL4636242 Ki = 928.0 nM 6.03
CHEMBL4636318 Ki = 1111.0 nM 5.95