Assay Detail
Functional
CHEMBL4629073
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Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Drug repurposing and rediscovery: Design, synthesis and preliminary biological evaluation of 1-arylamino-3-aryloxypropan-2-ols as anti-melanoma agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.90 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647987 | — | — | 1 | 5.70 |
| CHEMBL4632553 | — | — | 1 | 5.64 |
| CHEMBL4646099 | — | — | 1 | 5.28 |
| CHEMBL4640999 | — | — | 1 | 5.25 |
| CHEMBL4649826 | — | — | 1 | 5.18 |
| CHEMBL4513932 | — | — | 1 | 5.16 |
| CHEMBL4647396 | — | — | 1 | 5.08 |
| CHEMBL4641718 | — | — | 1 | 4.97 |
| CHEMBL263149 | — | — | 1 | 4.96 |
| CHEMBL723 | CARVEDILOL | 4.0 | 1 | 4.89 |
| CHEMBL4161940 | — | — | 1 | 4.87 |
| CHEMBL2440845 | — | — | 1 | 4.86 |
| CHEMBL4646676 | — | — | 1 | 4.86 |
| CHEMBL4648268 | — | — | 1 | 4.85 |
| CHEMBL4643089 | — | — | 1 | 4.84 |
| CHEMBL3799125 | — | — | 1 | 4.83 |
| CHEMBL2440846 | — | — | 1 | 4.79 |
| CHEMBL2440825 | — | — | 1 | 4.72 |
| CHEMBL4633203 | — | — | 1 | 4.68 |
| CHEMBL4640312 | — | — | 1 | 4.65 |
| CHEMBL4637718 | — | — | 1 | 4.65 |
| CHEMBL4641529 | — | — | 1 | 4.55 |
| CHEMBL4638494 | — | — | 1 | 4.50 |
| CHEMBL324665 | CARAZOLOL | 2.0 | 1 | 4.45 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 4.22 |
| CHEMBL768 | ESMOLOL | 4.0 | 1 | - |
| CHEMBL499 | TIMOLOL | 4.0 | 1 | - |
| CHEMBL13 | METOPROLOL | 4.0 | 1 | - |
| CHEMBL645 | BISOPROLOL | 4.0 | 1 | - |
| CHEMBL471 | SOTALOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647987 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4632553 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL4646099 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL4640999 | — | IC50 | = | 5560.0 | nM | 5.25 |
| CHEMBL4649826 | — | IC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL4513932 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL4647396 | — | IC50 | = | 8370.0 | nM | 5.08 |
| CHEMBL4641718 | — | IC50 | = | 10760.0 | nM | 4.97 |
| CHEMBL263149 | — | IC50 | = | 10980.0 | nM | 4.96 |
| CHEMBL723 | CARVEDILOL | IC50 | = | 13010.0 | nM | 4.89 |
| CHEMBL4161940 | — | IC50 | = | 13480.0 | nM | 4.87 |
| CHEMBL2440845 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL4646676 | — | IC50 | = | 13880.0 | nM | 4.86 |
| CHEMBL4648268 | — | IC50 | = | 14130.0 | nM | 4.85 |
| CHEMBL4643089 | — | IC50 | = | 14280.0 | nM | 4.84 |
| CHEMBL3799125 | — | IC50 | = | 14740.0 | nM | 4.83 |
| CHEMBL2440846 | — | IC50 | = | 16330.0 | nM | 4.79 |
| CHEMBL2440825 | — | IC50 | = | 18870.0 | nM | 4.72 |
| CHEMBL4633203 | — | IC50 | = | 21090.0 | nM | 4.68 |
| CHEMBL4640312 | — | IC50 | = | 22270.0 | nM | 4.65 |
| CHEMBL4637718 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL4641529 | — | IC50 | = | 28230.0 | nM | 4.55 |
| CHEMBL4638494 | — | IC50 | = | 31760.0 | nM | 4.50 |
| CHEMBL324665 | CARAZOLOL | IC50 | = | 35420.0 | nM | 4.45 |
| CHEMBL27 | PROPRANOLOL | IC50 | = | 59500.0 | nM | 4.22 |
| CHEMBL768 | ESMOLOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL499 | TIMOLOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL13 | METOPROLOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL645 | BISOPROLOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL471 | SOTALOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL429 | LABETALOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL24 | ATENOLOL | IC50 | > | 100000.0 | nM | - |